Example orders for weekly 5-FU & Leucovorin in colon cancer

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Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.

Weekly 5-FU & Leucovorin

Original references may be found at weekly 5-FU & Leucovorin

Example regimen #1

28-day cycles

Supportive therapy

  • Prochlorperazine (Compazine) 10 mg PO prn nausea


  • 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.


  • Hold if patient has significant diarrhea/mucositis, ANC less than 1000, or platelets less than 100 and notify physician.


  • My institution administers this regimen with a 3 weeks on, 1 week off schedule for every 28-day cycle.