Example orders for Sipuleucel-T (Provenge) in prostate cancer

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Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.

Sipuleucel-T (Provenge)

Published regimens and references can be found on the prostate cancer page.

Example order set #1

  • Sipuleucel-T (Provenge) 1 bag IV over 60 minutes once per day on days 1, 15, 29. Prior to administration, gently agitate bag of sipuleucel-T to resuspend. Use standard tubing without a filter.

Supportive therapy

  • Acetaminophen (Tylenol) 650 mg PO once; 30 minutes prior to infusion
  • Diphenhydramine (Benadryl) 25 to 50 mg PO once; 30 minutes prior to infusion


  • Confirm that patient has not had fevers or chills prior to receiving acetaminophen so that staff can property monitoring for side effects from sipuleucel-T infusion.
  • Observe patient for at least 30 minutes after each infusion in case the patient develops an acute infusion reaction.


  • Patients without central lines: insert peripheral IV before therapy. Flush peripheral IV with 10 mL 0.9% normal saline after each day's dose of chemotherapy. Remove peripheral IV when therapy is complete.
  • Patients with central lines: access the central venous access device before therapy. Flush central line according to institutional guidelines after each day's dose of chemotherapy. Deaccess device when therapy is complete.