Class/mechanism from the NCI Drug Dictionary: A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system.
Extravasation: no information
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Diseases for which it is used
History of changes in FDA indication
- 11/20/2018: Initial approval for adult and pediatric (newborn and older) patients with primary hemophagocytic lymphohistiocytosis (HLH) with refractory, recurrent or progressive disease or intolerance with conventional HLH therapy.
Patient Drug Information
Also known as
- Code name: NI-0501
- Generic name: emapalumab-lzsg
- Brand name: Gamifant