Class/mechanism from the NCI Drug Dictionary: A human monoclonal antibody against the cytokine interferon-gamma (IFN-gamma; IFNg), with potential immunomodulating activity. Upon administration, emapalumab binds to and neutralizes IFNg. This inhibits IFNg-mediated signaling pathways and suppresses the activation of the immune system.
Extravasation: no information
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Diseases for which it is used
History of changes in FDA indication
- 2018-11-20: Initial approval for adult and pediatric (newborn and older) patients with primary hemophagocytic lymphohistiocytosis (HLH) with refractory, recurrent or progressive disease or intolerance with conventional HLH therapy. (Based on NI-0501-04)
Patient Drug Information
Also known as
- Code name: NI-0501
- Generic name: emapalumab-lzsg
- Brand name: Gamifant