Class/mechanism: Humanized IgG1 monoclonal antibody which targets SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7). SLAMF7 is a protein which is expressed on myeloma cells, Natural Killer cells, plasma cells, and expressed at lower levels on certain immune cell subsets of differentiated cells. Elotuzumab facilitates antibody-dependent cellular cytotoxicity (ADCC) between myeloma cells and Natural Killer cells. The antigen target of elotuzumab may also be known as CS1 (CD2 subset 1, CRACC, SLAMF7).
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 5/19/2014: Granted FDA Breakthrough Therapy designation "for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma in patients who have received one or more prior therapies."
- 11/30/2015: FDA approved to be used "in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies."
Also known as
- Code names: BMS-901608, HuLuc63, PDL063, PDL-063
- Generic name: anti-CS1 monoclonal antibody HuLuc63
- Brand name: Empliciti