Deferoxamine (Desferal)

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Also known as desferrioxamine B, desferoxamine B, DFO-B, DFOA, or DFB.

General information

Class/mechanism: Iron chelating agent; chelates iron from ferritin and hemosiderin but not easily from transferrin. Does not combine with iron from hemoglobin and cytochromes. The chelate is soluble in water and is excreted by the kidney (as well as the bile), which causes urine to appear reddish.[1][2]
Route: IM, SC, IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information


  1. 1.0 1.1 Deferoxamine (Desferal) package insert
  2. Deferoxamine (Desferal) package insert (locally hosted backup)
  3. Deferoxamine (Desferal) patient drug information (UpToDate)