Clodronate (Bonefos)

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Not FDA approved; used in several other countries (Canada, Australia, the United Kingdom, Italy, others).

Also known as Clasteon, Clastoban, Climaclod, Clodeosten, Clodran, Clodron, Clodron 1A Pharma, Clodron Beta, Clodron Hexal, Clodronate DE Sodium G GAM, clodronate disodium, clodronic acid disodium tetrahydrate, Clody, Difosfonal, DIS.clodr.ATE, Disdual, Lodronat, Lodronat 520, Loron, Loron 520, LUO QU, Lytos, Mebonat, Moticlod, Niklod, Ossiten, Ostac 520, Osteonorm, Osteostab, Sindronat.

General information

Class/mechanism: Bisphosphonate, inhibits osteoclast activity, dissolution of hydroxyapatite crystals, and bone resorption/turnover.[1][2]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information


  1. 1.0 1.1 Clodronate (Bonefos) package insert
  2. Clodronate (Bonefos) package insert (locally hosted backup)
  3. Clodronate (Bonefos) patient drug information (UpToDate)