Calcium phosphate rinse (Caphosol)

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General information

Class/mechanism: Electrolyte solution designed to mimic the ionic and pH balance of human saliva. The solution is used to help maintain moisture in mucosa of the mouth, tongue, and throat in patients experiencing xerostomia/hyposalivation or mucositis.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Conditions for which it is used

  • Xerostomia/hyposalivation
  • Mucositis

Patient drug information

Also known as

  • Generic names: artificial saliva, supersaturated calcium phosphate rinse
  • Brand name solutions with similar uses include: Aquoral, Biotene Moisturizing Mouth Spray, Biotene Oral Balance, Entertainer's Secret, Moi-Stir, Mouth Kote, Numoisyn, Oasis, and SalivaSure.


  1. 1.0 1.1 1.2 Calcium phosphate rinse (Caphosol) package insert
  2. Calcium phosphate rinse (Caphosol) package insert (locally hosted backup)
  3. Caphosol manufacturer's website
  4. Artificial saliva patient drug information (UpToDate)