Borofalan-10B (Steboronine)

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Mechanism of action

From the NCI Drug Dictionary]: A boronated phenylalanine and boron (boron-10) carrier that may be used in boron neutron capture therapy (BNCT), with potential antineoplastic activity. Upon administration, borofalan (10B) is absorbed mostly by tumor cells. When exposed to neutron irradiation, borofalan (10B) absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells spares adjacent normal tissues.

Diseases for which is used

History of changes in PMDA indication

  • 2020-03-25: Newly indicated for the treatment of locally unresectable recurrent or unresectable advanced head and neck cancer.

Also known as

  • Code name: SPM-011
  • Brand name: Borofalan