Bicalutamide (Casodex)

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General information

Class/mechanism: Antiandrogen; non-steroidal androgen receptor inhibitor that competitively inhibits androgens by binding to cytosol androgen receptors.[1]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, MedscapeUpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 10/4/1995: Initial FDA approval
  • 5/11/2005: Indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analogue for the treatment of Stage D2 metastatic carcinoma of the prostate.

Also known as

  • Brand names: Casodex, Cosudex, Calutide, Kalumid


  1. 1.0 1.1 1.2 Bicalutamide (Casodex) package insert (locally hosted backup)
  2. Bicalutamide (Casodex) patient drug information (Chemocare)
  3. Bicalutamide (Casodex) patient drug information (UpToDate)