Belinostat (Beleodaq)

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General information

Class/mechanism: Histone deacetylase (HDAC) inhibitor. Belinostat causes cell cycle arrest and/or apoptosis of tumor cells by blocking HDAC, which results in accumulation of acetylated histones and other proteins.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code name: PXD101
  • Brand name: Beleodaq


  1. 1.0 1.1 1.2 Belinostat (Beleodaq) package insert
  2. Belinostat (Beleodaq) package insert (locally hosted backup)
  3. Beleodaq manufacturer's website
  4. Belinostat (Beleodaq) patient drug information (Chemocare)
  5. Belinostat (Beleodaq) patient drug information (UpToDate)