BE-CAR7
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Mechanism of action
Base-edited ("off the shelf") CAR T-cells directed against CD7
Preliminary data
- Chiesa R, Georgiadis C, Syed F, Zhan H, Etuk A, Gkazi SA, Preece R, Ottaviano G, Braybrook T, Chu J, Kubat A, Adams S, Thomas R, Gilmour K, O'Connor D, Vora A, Qasim W; Base-Edited CAR T Group. Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia. N Engl J Med. 2023 Sep 7;389(10):899-910. Epub 2023 Jun 14. link to original article PubMed ISRCTN15323014