Atovaquone (Mepron)

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General information

Class/mechanism: Antiprotozoal, antimicrobial. Hydroxy-1,4-naphthoquinone, analog of ubiquinone, with antipneumocystis activity. Exact mechanism unclear, but may involve inhibition of the electron transport chain in mitochondria and downstream inhibition of nucleic acid and ATP synthesis.[1][2]
Route: PO (typically as liquid suspension)
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

No known antineoplastic properties.

Patient drug information

References

  1. 1.0 1.1 Atovaquone (Mepron) package insert
  2. Atovaquone (Mepron) package insert (locally hosted backup)
  3. Atovaquone (Mepron) patient drug information (UpToDate)