Argatroban (Acova)

From - A Hematology Oncology Wiki
Jump to: navigation, search

General information

Class/mechanism: Direct thrombin inhibitor, binds reversibly to free and clot-associated thrombin and inhibits its effects of catalyzing the formation of fibrin from fibrinogen, platelet aggregation, activation of protein C, and activation of coagulation factors V, VIII, and XIII.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information


  1. 1.0 1.1 1.2 Argatroban package insert
  2. Argatroban package insert (locally hosted backup)
  3. Argatroban manufacturer's website
  4. Argatroban patient drug information (UpToDate)