Aprepitant (Emend)

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General information

Class/mechanism: Substance P/neurokinin 1 (NK1) receptor antagonist. Aprepitant is able to cross the blood-brain barrier and blocks substance P activation of tachykinin family neurokinin 1 (NK1) receptors, which reduces the incidence of acute and delayed emesis.[1][2][3]
Route: PO/IV
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

History of changes in FDA indication

  • 2003-03-26: Approved for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy, including high-dose cisplatin.
  • 2005-10-28: Approved for prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
  • 2006-06-30: Approved for the prevention of postoperative nausea and vomiting.

History of changes in EMA indication

  • 2003-11-11: Initial authorization

Also known as

  • Code name: MK-0869
  • Brand names: Aponvie, Cinvanti, Emend, Emend Trifold