Antithrombin III (human and recombinant)

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May be known as antithrombin (human), antithrombin (recombinant), ATryn, or Thrombate III.

General information

Class/mechanism: Inhibitor of thrombin, which converts fibrinogen to fibrin in the coagulation cascade and subsequent development of thrombus. Clinical applications include management of patients with hereditary antithrombin III (AT-III) deficiency. Please choose from the products below to find specific drug/manufacturer information:

  • Antithrombin III, human (Thrombate III)[1][2][3]
  • Antithrombin III, recombinant (ATryn)[4][5][6]

Route: IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[2][5]

Patient drug information


  1. Thrombate III manufacturer's website
  2. 2.0 2.1 Antithrombin III, human (Thrombate III) package insert
  3. Antithrombin III, human (Thrombate III) package insert (locally hosted backup)
  4. ATryn manufacturer's website
  5. 5.0 5.1 5.2 Antithrombin III, recombinant (ATryn) package insert
  6. Antithrombin III, recombinant (ATryn) package insert (locally hosted backup)
  7. Antithrombin III (human and recombinant) patient drug information (UpToDate)