Allopurinol (Zyloprim)

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General information

Class/mechanism: Xanthine oxidase inhibitor.
Route: PO/IV
Extravasation: unknown

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

No known antineoplastic properties. Used for tumor lysis syndrome treatment/prophylaxis.

History of changes in FDA indication

  • 8/19/1966: Initial FDA approval

Also known as

  • Brand names: Abloric, Aloprim, Caplenal, Milurit, Zyloprim, Zyloric, Zyoway