Custirsen (OGX-011)
General information
Class/mechanism: Clusterin inhibitor. Clusterin is upregulated in cancer cells in response to antineoplastic treatment and is hypothesized to play a role in cancer cell survival and treatment resistance. Increased clusterin production has been associated with increased rates of progression, treatment resistance, and shorter survival. Inhibiting clusterin is hypothesized to decrease the rates of tumor growth and resistance to other treatments.[1][2]
Route: IV
Extravasation: no information
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Preliminary data
Non-small cell lung cancer
- Laskin JJ, Nicholas G, Lee C, Gitlitz B, Vincent M, Cormier Y, Stephenson J, Ung Y, Sanborn R, Pressnail B, Nugent F, Nemunaitis J, Gleave ME, Murray N, Hao D. Phase I/II trial of custirsen (OGX-011), an inhibitor of clusterin, in combination with a gemcitabine and platinum regimen in patients with previously untreated advanced non-small cell lung cancer. J Thorac Oncol. 2012 Mar;7(3):579-86. PubMed
Prostate cancer
- Saad F, Hotte S, North S, Eigl B, Chi K, Czaykowski P, Wood L, Pollak M, Berry S, Lattouf JB, Mukherjee SD, Gleave M, Winquist E; Canadian Uro-Oncology Group. Randomized phase II trial of Custirsen (OGX-011) in combination with docetaxel or mitoxantrone as second-line therapy in patients with metastatic castrate-resistant prostate cancer progressing after first-line docetaxel: CUOG trial P-06c. Clin Cancer Res. 2011 Sep 1;17(17):5765-73. Epub 2011 Jul 25. PubMed
Patient drug information
No information available.
Also known as
- Code name: OGX-011