Elotuzumab (Empliciti)
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General information
Class/mechanism from NCI Drug Dictionary: A humanized monoclonal antibody directed against the human CS1 (CD2 subset 1, CRACC, SLAMF7) antigen with potential antineoplastic activity. Elotuzumab binds to the CS1 antigen, which may trigger antibody-dependent cellular cytotoxicity (ADCC) in cells expressing CS1.[1]
Route: IV
Extravasation: no information
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Diseases for which it is used
Patient drug information
No information available.
History of changes in FDA indication
- 5/19/2014: Granted FDA Breakthrough Therapy designation "for use in combination with lenalidomide and dexamethasone for the treatment of multiple myeloma in patients who have received one or more prior therapies."
- 11/30/2015: FDA approved "in combination with lenalidomide and [[Dexamethasone (Decadron) | dexamethasone] for the treatment of patients with multiple myeloma who have received one to three prior therapies."
Also known as
HuLuc63