How I Treat

The "How I Treat" series has been published by Blood for several decades and covers a wide variety of topics in malignant and classical hematology. While these articles are not considered to be formal guidelines, they are considered highly reputable sources of expert opinion. They cover topics ranging from commonly encountered hematologic conditions with a large evidence base, to very rare conditions with only case reports to guide treatment. The purpose of this page is to consolidate the links to all known published How I Treat articles.

In the first two sections (malignant hematology and classical hematology), articles are presented by condition, in reverse chronological order. In the third section, articles are gathered under "special considerations" such as pregnancy and hematologic disease. Given the rapid change in evidence in many areas of hematology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

Note: this page is currently under construction.

Malignant hematology

Myeloid neoplasms

Acute lymphoblastic leukemia (ALL)

• 2023: Kopmar & Cassaday. How I prevent and treat central nervous system disease in adults with acute lymphoblastic leukemia PubMed
• 2023: Myers et al. How I use risk factors for success or failure of CD19 CAR T cells to guide management of children and AYA with B-cell ALL PubMed
• 2023: Si Lim et al. How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults PubMed
• 2020: Aldoss & Douer. How I treat the toxicities of pegasparaginase in adults with acute lymphoblastic leukemia PubMed
• 2020: Aldoss & Forman. How I treat adults with advanced acute lymphoblastic leukemia eligible for CD19-targeted immunotherapy PubMed
• 2020: Hunger & Raetz. How I treat relapsed acute lymphoblastic leukemia in the pediatric population PubMed
• 2020: Teachey & O'Connor How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children PubMed
• 2019: Ravandi. How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia PubMed
• 2015: Curran & Stock. How I treat acute lymphoblastic leukemia in older adolescents and young adults PubMed
• 2015: Frey & Luger. How I treat adults with relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia PubMed

Acute myeloid leukemia (AML)

• 2023: Biederstädt & Rezvani. How I treat high-risk acute myeloid leukemia using preemptive adoptive cellular immunotherapy PubMed
• 2021: Falini et al. How I diagnose and treat NPM1-mutated AML PubMed
• 2021: Rubnitz & Kaspers. How I treat pediatric acute myeloid leukemia PubMed
• 2020: DeWolf & Tallman. How I treat relapsed or refractory AML PubMed
• 2020: DiNardo & Wei. How I treat acute myeloid leukemia in the era of new drugs PubMed
• 2016: Ofran et al. How I treat acute myeloid leukemia presenting with preexisting comorbidities PubMed
• 2015: Röllig & Ehninger. How I treat hyperleukocytosis in acute myeloid leukemia PubMed
• 2014: Ossenkoppele & Löwenberg. How I treat the older patient with acute myeloid leukemia PubMed
• 2011: Bakst et al. How I treat extramedullary acute myeloid leukemia PubMed

Chronic myeloid leukemia (CML)

• 2022: Berman. How I treat chronic-phase chronic myelogenous leukemia
• 2019: Hijiya & Suttorp. How I treat chronic myeloid leukemia in children and adolescents

Myelodysplastic syndrome (MDS)

• 2019: Santini How I treat MDS after hypomethylating agent failure
• 2013: Sekeres & Cutler How we treat higher-risk myelodysplastic syndromes PubMed
• 2013: Fenaux & Adès How we treat lower-risk myelodysplastic syndromes

Polycythemia vera (PV)

• 2014: Vannucchi How I treat polycythemia vera PubMed

Lymphoid neoplasms

Adult T-cell leukemia-lymphoma (ATLL)

• 2021: Cook & Phillips How I treat adult T-cell leukemia/lymphoma PubMed

Castleman disease

• 2010: Bower. How I treat HIV-associated multicentric Castleman disease PubMed

Chronic lymphocytic leukemia (CLL/SLL)

• 2021: Lew et al. How I treat chronic lymphocytic leukemia after venetoclax
• 2019: Stephens & Byrd. How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia
• 2018: Brown. How I treat CLL patients with ibrutinib PubMed

Cutaneous T-cell lymphoma (CTCL)

• 2019: Shinohara & Shustov How I treat primary cutaneous CD30 + lymphoproliferative disorders

Hodgkin lymphoma

• 2021: Epperla & Herrera How I incorporate novel agents into the treatment of classical Hodgkin lymphoma
• 2020: Eichenauer & Engert How I treat nodular lymphocyte-predominant Hodgkin Lymphoma

Diffuse large B-cell lymphoma (DLBCL)

• 2023: Lugtenburg & Mutsaers How I treat older patients with DLBCL in the frontline setting PubMed

Follicular lymphoma (FL)

• 2019: Casulo & Barr How I treat early-relapsing follicular lymphoma PubMed

Large granular lymphocytic leukemia (T-LGL)

• 2011: Lamy & Loughran. How I treat LGL leukemia PubMed

NK- and T-cell lymphoma

• 2013: Tse & Kwong How I treat NK/T-cell lymphomas PubMed

Prolymphocytic leukemia (T-PLL)

• 2012: Dearden How I treat prolymphocytic leukemia PubMed

Waldenström macroglobulinemia (WM)

• 2019: Dimopoulos & Kastritis. How I treat Waldenström macroglobulinemia PubMed

Plasma cell dyscrasias

Light-chain (AL) amyloidosis

• 2022: Palladini & Merlini How I treat AL amyloidosis

Multiple myeloma

• 2023: van de Donk How We Manage Newly Diagnosed Multiple Myeloma With Circulating Tumor Cells
• 2022: Zamagni et al. How I treat high-risk multiple myeloma
• 2022: Kastritis et al. How I treat relapsed multiple myeloma
• 2022: Vaxman & Gertz How I approach smoldering multiple myeloma

Histiocytic disorders

Hemophagocytic lymphohistiocytosis (HLH)

• 2015: Schram & Berliner. How I treat hemophagocytic lymphohistiocytosis in the adult patient PubMed

Classical hematology

Hemostasis and thrombosis

Acquired thrombotic thrombocytopenic purpura (aTTP)

• 2022: Akwaa et al. How I treat immune-mediated thrombotic thrombocytopenic purpura after hospital discharge
• 2020: Ferrari & Peyvandi. How I treat thrombotic thrombocytopenic purpura in pregnancy

Antiphospholipid antibody syndrome (APS)

• 2021: Cohen & Isenberg. How I treat anticoagulant-refractory thrombotic antiphospholipid syndrome PubMed

Hemophilia

• 2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
• 2019: Young. How I treat children with haemophilia and inhibitors

Thrombotic microangiopathy (TMA)

• 2023: Doreille et al. How I treat thrombotic microangiopathy in the era of rapid genomics
• 2021: Thomas & Scully. How I treat microangiopathic hemolytic anemia in patients with cancer

Venous thromboembolism (VTE)

• 2022: Schmidt & Lee. How I treat and prevent venous thrombotic complications in patients with lymphoma
• 2020: Klok & Huisman. How I assess and manage the risk of bleeding in patients treated for venous thromboembolism
• 2020: Middeldorp & Ganzevoort. How I treat venous thromboembolism in pregnancy
• 2020: Wang & Carrier. How I treat obese patients with oral anticoagulants
• 2019: Pabinger & Thaler. How I treat patients with hereditary antithrombin deficiency
• 2019: Chan & Eikelbloom. How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism
• 2019: Kraaijpoel & Carrier. How I treat cancer-associated venous thromboembolism
• 2018: Shet & Wun. How I diagnose and treat venous thromboembolism in sickle cell disease

von Willebrand disease (vWD)

• 2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
• 2019: Lavin & O'Donnell. How I treat low von Willebrand factor levels

Special considerations

Pregnancy

• 2020: Ferrari & Peyvandi. How I treat thrombotic thrombocytopenic purpura in pregnancy
• 2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
• 2020: Middeldorp & Ganzevoort. How I treat venous thromboembolism in pregnancy