Thrombocytopenia and platelet dysfunction
Revision as of 20:17, 5 April 2023 by Warner-admin (talk | contribs) (Warner-admin moved page Thrombocytopenia to Thrombocytopenia and platelet dysfunction)
Guidelines
"How I Treat"
- 2022: Stanworth & Shah How I use platelet transfusions
- 2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
- 2021: Kyrle & Eichinger How I manage cyclic thrombocytopenia
Definition of thrombocytopenia
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP