Retifanlimab (Zynyz)
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Mechanism of action
From NCI Drug Dictionary: A proprietary humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, retifanlimab binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T cells and cell-mediated immune responses against tumor cells.
Diseases for which it is used
History of changes in FDA indication
- 3/22/2023: Granted accelerated approval for adult patients with metastatic or recurrent locally advanced Merkel cell carcinoma (MCC). (Based on PODIUM-201)
Also known as
- Code name: INCMGA 0012, MGA 012
- Generic name: retifanlimab-dlwr
- Brand name: Zynyz