Non-small cell lung cancer, CNS metastases

From HemOnc.org - A Hematology Oncology Wiki
Revision as of 13:58, 25 January 2023 by Jwarner (talk | contribs) (Created page with "<span id="BackToTop"></span> <div class="noprint" style="background-color:LightGray; position:fixed; bottom:2%; right:0.25%; padding-left:5px; padding-right:5px; margin: 15px;...")
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

Back to Top

Section editor transclusions

15 regimens on this page
17 variants on this page


All lines of therapy

Dexamethasone monotherapy

Regimen

Study Evidence Comparator Comparative Efficacy Comparative Toxicity
Mulvenna et al. 2016 (QUARTZ) Phase 3 (E-de-esc) Dexamethasone & WBRT Inconclusive whether non-inferior QALYs

Supportive therapy

References

  1. QUARTZ: Mulvenna P, Nankivell M, Barton R, Faivre-Finn C, Wilson P, McColl E, Moore B, Brisbane I, Ardron D, Holt T, Morgan S, Lee C, Waite K, Bayman N, Pugh C, Sydes B, Stephens R, Parmar MK, Langley RE. Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Lancet. 2016 Oct 22;388(10055):2004-2014. Epub 2016 Sep 4. link to original article link to PMC article PubMed ISRCTN3826061

Dexamethasone & WBRT

Regimen

Study Evidence Comparator Comparative Efficacy Comparative Toxicity
Mulvenna et al. 2016 (QUARTZ) Phase 3 (C) Dexamethasone Inconclusive whether non-inferior QALYs

Radiotherapy

  • WBRT, 20 Gy in 5 fractions

Supportive therapy

References

  1. QUARTZ: Mulvenna P, Nankivell M, Barton R, Faivre-Finn C, Wilson P, McColl E, Moore B, Brisbane I, Ardron D, Holt T, Morgan S, Lee C, Waite K, Bayman N, Pugh C, Sydes B, Stephens R, Parmar MK, Langley RE. Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial. Lancet. 2016 Oct 22;388(10055):2004-2014. Epub 2016 Sep 4. link to original article link to PMC article PubMed ISRCTN3826061

Teniposide & WBRT

Regimen

Study Years of enrollment Evidence Comparator Comparative Efficacy
Postmus et al. 2000 1989-1995 Phase 3 (E-esc) Teniposide Might have superior OS

Chemotherapy

Radiotherapy

  • WBRT, 30 Gy in 10 fractions

References

  1. Postmus PE, Haaxma-Reiche H, Smit EF, Groen HJ, Karnicka H, Lewinski T, van Meerbeeck J, Clerico M, Gregor A, Curran D, Sahmoud T, Kirkpatrick A, Giaccone G; European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group. Treatment of brain metastases of small-cell lung cancer: comparing teniposide and teniposide with whole-brain radiotherapy--a phase III study of the European Organization for the Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol. 2000 Oct 1;18(19):3400-8. link to original article PubMed
Retrieved from "https://hemonc.org/w/index.php?title=Non-small_cell_lung_cancer,_CNS_metastases&oldid=65742"