BL22 immunotoxin (CAT-3888)
In clinical trials. Also known as GCR-3888. Related to GCR-8015/CAT-8015, which have increased affinity to CD22.
General information
Class/mechanism: Recombinant anti-CD22 immunotoxin fusion protein comprised of a murine anti-CD22 antibody fragment (disulphide-linked Fv, dsFv) and Pseudomonas exotoxin PE38. BL22 binds to CD22 positive cells and is endocytosed, resulting in intracellular release of the toxin and cell death.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.
Clinical trials
- Cladribine With Simultaneous or Delayed Rituximab to Treat Hairy Cell Leukemia
- Retreatment Protocol for BL22 Immunotherapy in Relapsed or Refractory Hairy Cell Leukemia
- BL22 Immunotoxin in Treating Patients Previously Treated With Cladribine for Hairy Cell Leukemia
Patient drug information
No information available.
References
- ↑ Cambridge Antibody Technology Group PLC (CATG) Acquires Oncology Product Candidates From Genencor International, Inc.
- ↑ R. J. Kreitman, W. H. Wilson, M. Stetler-Stevenson, P. Noel, I. Pastan. Long term follow-up of BL22 in cladribine-resistant hairy cell leukemia. 2004 ASCO Annual Meeting abstract 6624.
- ↑ R. J. Kreitman, W. H. Wilson, M. Stetler-Stevenson, P. Noel, D. J. FitzGerald, I. Pastan. Phase II trial of CAT-3888 (BL22) in chemo-resistant hairy cell leukemia. 2007 ASCO Annual Meeting abstract 7095.