Sorafenib Dosing Nomogram
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AAML1031 Sorafenib Dosing Nomogram
| BSA Range (m2) | Dose Level 0 (100 mg/m2/day once daily) | Dose Level 1 (200 mg/m2/day once daily) | Dose Level 2 (300 mg/m2/day divided BID) |
|---|---|---|---|
| ≤ 0.35 | 50 mg x 4 days/week,
0 x 3 day/week (200 mg) |
50 mg x 5 days/week,
100 mg x 2 days/week (450 mg) |
50 mg twice daily x 7 days/week
(700 mg) |
| 0.36 - 0.4 | 50 mg x 5 days/week,
0 x 2 day/week (250 mg) |
50 mg x 4 days/week,
100 mg x 3 days/week (500 mg) |
50 mg twice daily x 6 days/week +
100 mg twice daily x 1 day/week (800 mg) |
| 0.41 - 0.45 | 50 mg x 6 days/week,
0 x 1 day/week (300 mg) |
50 mg x 2 days/week,
100 mg x 5 days/week (600 mg) |
50 mg twice daily x 5 days/week +
100 mg twice daily x 2 days/week (900 mg) |
| 0.46 - 0.55 | 50 mg x 7 days/week
(350 mg) |
100 mg x 7 days/week
(700 mg) |
50 mg q AM +100 mg q PM
x 7 days/week (1050 mg) |
| 0.56 - 0.6 | 50 mg x 6 days/week,
100 mg x 1 day/week (400 mg) |
100 mg x 6 days/week,
200 mg x 1 day/week (800 mg) |
50 mg twice daily x 2 days/week +
100 mg twice daily x 5 days/week (1200 mg) |
| 0.61 - 0.7 | 50 mg x 5 days/week,
100 mg x 2 days/week (450 mg) |
100 mg x 5 days/week,
200 x 2 days/week (900 mg) |
100 mg twice daily x 7 days/week
(1400 mg) |
| 0.71 - 0.8 | 50 mg x4 days/week,
100 mg x3 days/week (500 mg) |
150 mg x 7 days/week
(1050mg) |
100 mg twice daily x 5 days/week +
150 mg twice daily x 2 days/week (1600 mg) |
| 0.81 - 0.9 | 50 mg x 2 days/week,
100 mg x 5 days/week (600 mg) |
150 mg x 4 days/week,
200 mg x 3 days/week (1200 mg) |
100 mg q AM + 150 mg q PM
x 7 days/week (1750 mg) |
| 0.91 - 01.05 | 100 mg x 7 days/week
(700 mg) |
200 mg x 7 days/week
(1400 mg) |
150 mg twice daily x 7 days/week
(2100 mg) |
| 1.06 - 1.2 | 100 mg x 6 days/week,
200 mg x1 day/week (800 mg) |
200
mg x 3 days/week, 250 mg x 4 days/week (1600 mg) |
150 mg q AM + 200 mg q PM
x 7 days/week (2450 mg) |
| 1.21 - 1.35 | 100 mg x 5 days/week,
200 mg x 2 days/week (900 mg) |
250 mg x 7 days/week
(1750 mg) |
200 mg twice daily x 7 days/week
(2800 mg) |
| 1.36 - 1.6 | 100 mg x 4 days/week,
200 mg x 3 days/week (1000 mg) |
300 mg x 7 days/week
(2100 mg) |
200 mg q AM + 250 mg q PM
x 7 days/week (3150 mg) |
| 1.61 - 1.7 | 100 mg x 2 days/week,
200 mg x 5 days/week (1200 mg) |
350 mg x 7 days/week
(2450 mg) |
250 mg twice daily x 7
days/week (3500 mg) |
| 1.71 - 1.85 | 100 mg x 1 day/week,
200 mg x 6 days/week (1300 mg) |
350 mg x 3 days/week
400 mg x 4 days/week (2650 mg) |
250 mg q AM + 300 mg q PM
x 7 days/week (3850 mg) |
| ≥ 1.86 | 200 mg x 7 days/week
(1400 mg) |
400 mg x 7 days/week
(2800 mg) |
300 mg twice daily x 7 days /week
(4200 mg) |