Sorafenib Dosing Nomogram

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Wayne H. Liang, MD, MS, FAMIA
Children’s Healthcare of Atlanta/Emory
Atlanta, GA

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AAML1031 Sorafenib Dosing Nomogram

BSA Range (m2) Dose Level 0 (100 mg/m2/day once daily) Dose Level 1 (200 mg/m2/day once daily) Dose Level 2 (300 mg/m2/day divided BID)
≤ 0.35 50 mg x 4 days/week,

0 x 3 day/week (200 mg)

50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

50 mg twice daily x 7 days/week

(700 mg)

0.36 - 0.4 50 mg x 5 days/week,

0 x 2 day/week (250 mg)

50 mg x 4 days/week,

100 mg x 3 days/week (500 mg)

50 mg twice daily x 6 days/week +

100 mg twice daily x 1 day/week (800 mg)

0.41 - 0.45 50 mg x 6 days/week,

0 x 1 day/week (300 mg)

50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

50 mg twice daily x 5 days/week +

100 mg twice daily x 2 days/week (900 mg)

0.46 - 0.55 50 mg x 7 days/week

(350 mg)

100 mg x 7 days/week

(700 mg)

50 mg q AM +100 mg q PM

x 7 days/week (1050 mg)

0.56 - 0.6 50 mg x 6 days/week,

100 mg x 1 day/week (400 mg)

100 mg x 6 days/week,

200 mg x 1 day/week (800 mg)

50 mg twice daily x 2 days/week +

100 mg twice daily x 5 days/week (1200 mg)

0.61 - 0.7 50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

100 mg x 5 days/week,

200 x 2 days/week (900 mg)

100 mg twice daily x 7 days/week

(1400 mg)

0.71 - 0.8 50 mg x4 days/week,

100 mg x3 days/week (500 mg)

150 mg x 7 days/week

(1050mg)

100 mg twice daily x 5 days/week +

150 mg twice daily x 2 days/week (1600 mg)

0.81 - 0.9 50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

150 mg x 4 days/week,

200 mg x 3 days/week (1200 mg)

100 mg q AM + 150 mg q PM

x 7 days/week (1750 mg)

0.91 - 01.05 100 mg x 7 days/week

(700 mg)

200 mg x 7 days/week

(1400 mg)

150 mg twice daily x 7 days/week

(2100 mg)

1.06 - 1.2 100 mg x 6 days/week,

200 mg x1 day/week (800 mg)

200

mg x 3 days/week, 250 mg x 4 days/week (1600 mg)

150 mg q AM + 200 mg q PM

x 7 days/week (2450 mg)

1.21 - 1.35 100 mg x 5 days/week,

200 mg x 2 days/week (900 mg)

250 mg x 7 days/week

(1750 mg)

200 mg twice daily x 7 days/week

(2800 mg)

1.36 - 1.6 100 mg x 4 days/week,

200 mg x 3 days/week (1000 mg)

300 mg x 7 days/week

(2100 mg)

200 mg q AM + 250 mg q PM

x 7 days/week (3150 mg)

1.61 - 1.7 100 mg x 2 days/week,

200 mg x 5 days/week (1200 mg)

350 mg x 7 days/week

(2450 mg)

250 mg twice daily x 7

days/week (3500 mg)

1.71 - 1.85 100 mg x 1 day/week,

200 mg x 6 days/week (1300 mg)

350 mg x 3 days/week

400 mg x 4 days/week (2650 mg)

250 mg q AM + 300 mg q PM

x 7 days/week (3850 mg)

≥ 1.86 200 mg x 7 days/week

(1400 mg)

400 mg x 7 days/week

(2800 mg)

300 mg twice daily x 7 days /week

(4200 mg)