Alvocidib (Flavopiridol)

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Mechanism of action

Flavonoid alkaloid CDK9 kinase inhibitor

History of changes in FDA indication

4/13/2007: Granted orphan status for treatment of B-cell chronic lymphocytic leukemia (B-CLL) or prolymphocytic leukemia arising from CLL.
4/23/2014: Granted orphan designation for the treatment of patients with acute myeloid leukemia (AML)

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