Docetaxel (Taxotere)
General information
Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Docetaxel (Taxotere) patient drug information (Chemocare)[3]
- Docetaxel (Taxotere) package insert pages 16-17[1]
- Docetaxel (Taxotere) patient drug information (UpToDate)[4]
Also known as
Asodocel, Docetax, Docetaxel Comp, Docetaxel Delta Farma, Docetaxel Microsules, Docetaxel Sandoz, Docetere, Dolectran, Doxel, Doxetal, Oncodocel, Plustaxano, N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol, Neocel, NSC 628503, RP 56976, Taxotere Aventis, Taxotere Chugai, Texot, Trixotene.
References
- Drug index
- Chemotherapy
- Irritant chemotherapy
- Vesicant chemotherapy
- Microtubule inhibitors
- Taxanes
- Bone cancer medications
- Breast cancer medications
- Cancer of unknown primary medications
- Cervical cancer medications
- Esophageal cancer medications
- Head and neck cancer medications
- Melanoma medications
- Non-small cell lung cancer medications
- Ovarian cancer medications
- Pancreatic cancer medications
- Prostate cancer medications
- Sarcoma medications
- Small cell lung cancer medications