Lurbinectedin (Zepzelca)
General information
Class/mechanism: Alkylator, binds to the minor groove of DNA, which distorts the DNA helix toward the major groove. This binding interrupts normal cell function and interferes with the expression of several several transcription factors, DNA binding proteins, and DNA repair mechanisms, which interrupts cell cycle and leads to tumor death.[1][2][3]
Route: IV
Extravasation: no information to cite, but suspected vesicant due to its similarity to Trabectedin (Yondelis)
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Lurbinectedin (Zepzelca) package insert[1]
- Lurbinectedin (Zepzelca) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 6/15/2020: [Accelerated FDA approval] "for adult patients with metastatic small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy."
Also known as
- Code name: PM-01183
- Brand name: Zepzelca