HemOnc vocabulary concepts
This page has short descriptions and examples of the concepts that have been parsed into the HemOnc ontology. Note that this is NOT the full HemOnc chemotherapy regimen model, as there are still concepts that are in the process of being defined and parsed. For information about how to obtain a copy of the ontology please go to this page.
Condition-level concepts
Condition
In the HemOnc vocabulary, a condition is the granular level at which treatments have been evaluated. For example, Colon cancer and Rectal cancer are conditions, whereas Colorectal cancer is a Condition Class.
- Examples: acquired coagulopathy, acute myeloid leukemia, adrenocortical carcinoma
Condition Class
Condition classes are containers for a subset of conditions. Most of these are organized by anatomy or disease category.
- Examples: classical hematologic condition, leukemia, malignant solid neoplasm
Context
Context refers to the disease setting in which a treatment is administered. There are currently 33 contexts described in the HemOnc vocabulary, organized into a hierarchical structure with is a relationships.
- Examples: adjuvant therapy, non-curative first-line induction therapy, upfront therapy
- Example of relationships: adjuvant therapy is a post-definitive therapy is an upfront therapy is a curative therapy is an all lines of therapy
Protocol-level concepts
Protocol
A protocol is the ordered combination of one or more Regimens. We are in the process of introducing this concept into the vocabulary - stay tuned!
Regimen-level concepts
Cycle Sigs (new in version 2020-01-25)
The timing of regimen cycles is captured as separate and distinct from the individual drug SIG of each of the components of the regimen. These so-called "cycle sigs" are a property of the regimen, although there are some cases where different components of a regimen have different cycle sigs (e.g., chemoradiotherapy often has different timing parameters for the chemotherapy and the radiotherapy parts). In the OMOP version of the HemOnc vocabulary, these instructions are captured as character strings; we are also in the process of digesting them into component parts.
- Examples: 14-day cycle for up to 8 cycles, 21-day cycle for 4 cycles, 21-day cycle for up to 35 cycles (2 years)
Modality
Modality refers to the intended effect of the agents being used in the regimen. Note that this can be distinct from the mechanism of action. The classic example is rituximab, which is a chemotherapeutic in the regimen R-CHOP and an immunosuppressive agent when used as monotherapy for immune thrombocytopenia. Other examples are steroids, which can be hormonotherapy, chemotherapy, or supportive medications depending on the intended use. We follow the SEER/NAACCR guidelines for modality, which means e.g., that a chemoradiotherapy regimen will have two modalities (chemotherapy and radiotherapy). In the future, we will develop a combined modality concept class.
- Examples: anticoagulation, chemotherapy, immunotherapy
Regimen
A regimen is one or more components given concurrently with an intended disease-modifying effect.
- Examples: 7 plus 3d, 7 plus 3d and Midostaurin, R-CHOP
Regimen Stub
A regimen stub is something that would ordinarily be a regimen, but is missing details such as what are the individual components. The most common reason for this is that the regimen is described on HemOnc.org as a comparator to another regimen but there are no further details. This situation most commonly arises when an experimental comparator arm is not superior to the control arm, thus not meeting the criteria for inclusion on HemOnc.org.
- Examples: FULV and Trimetrexate, Plitidespin and Dexamethasone
Regimen Class (new in version 2020-01-25)
A regimen class is a collection of regimens based on a common theme. Regimen classes enable the aggregation of different but similar regimens, and are often referred to within FDA labels.
- Examples: platinum doublet, bevacizumab-containing regimen
Component-level concepts
Brand Name
These are US and non-US brand names for drugs.
- Examples: Abatoarin, Acetisal, Aclacin
Component
Examples: abciximab, abemaciclib, abexinostat
Component Class
Examples: 5 alpha-reductase inhibitor, AKT1 inhibitor, anthracycline
Procedure
Examples: adrenalectomy, lymphadenectomy, interval debulking surgery
Rad Sig
Example: 1.1 Gy fractions x 70 fractions, given twice per day, 5 times per week (total dose: 77 Gy)
Route
Examples: intravenous, oral, subcutaneous
Sig
Example: 0.4 mg/m^2/day IV continuous infusion over 96 hours, started on day 1 (total dose per cycle: 1.6 mg/m^2)
Sig Stub
Example: (dose not specified) IT once per day on days 22 and 43
Study-level concepts
Endpoint (new in version 2020-01-25)
Examples: CR rate after first induction, DFS36, OS
Experimental design (new in version 2020-01-25)
Examples: de-escalation, escalation, in-class switch, out-of-class switch
Study
Examples: ABSOLUTE, ACOSOG Z1031, ECOG E3483
Study Class (new in version 2020-01-25)
Example: FDA registration study
Study Group
Examples: Eastern Cooperative Oncology Group, EINSTEIN Investigators, EORTC Children Leukemia Group
Study name short
Examples: Adelstein et al. 2003, Adelstein et al. 2010, Alberts et al. 1989
Publication-level concepts
Journal
Examples: Blood Adv, N Engl J Med, Ann Oncol
PubMedURL
Most of the references included in the HemOnc vocabulary are also indexed in MEDLINE. When this is the case, we also include a direct hyperlink to the PubMed abstract.
Reference
Examples: ABSOLUTE::00, Abrey et al. 2000::01
ReferenceTitle
Example: A comparative study of two regimens of combination chemotherapy in acute leukemia
ReferenceURL
This is the direct hyperlink to the publication described by the Reference concept.
Author-level concepts
Author
Author names, in the format of Last-Name_First/Middle.
- Examples: Abbruzzese_Alberto, Abbruzzese_James L, Abernethy_Amy
Generic concepts
Year
Examples: 1946, 2020