HemOnc vocabulary concepts

This page has short descriptions and examples of the concepts that have been parsed into the HemOnc ontology. Note that this is NOT the full HemOnc chemotherapy regimen model, as there are still concepts that are in the process of being defined and parsed. For information about how to obtain a copy of the ontology please go to this page.

Condition-level concepts

Condition

Examples: acquired coagulopathy, acute myeloid leukemia, adrenocortical carcinoma

Condition Class

Examples: classical hematologic condition, leukemia, malignant solid neoplasm

Context

Examples: adjuvant therapy, non-curative first-line induction therapy, upfront therapy

Procedure

Examples: adrenalectomy, lymphadenectomy, interval debulking surgery

Regimen-level concepts

Cycle Sigs

Examples: 14-day cycle for up to 8 cycles, 21-day cycle for 4 cycles, 21-day cycle for up to 35 cycles (2 years)

Modality

Examples: anticoagulation, chemotherapy, immunotherapy

Regimen

Examples: 7 plus 3d, 7 plus 3d and Midostaurin, R-CHOP

Regimen Class

Examples: platinum doublet, bevacizumab-containing regimen

Regimen Stub

Examples: FULV and Trimetrexate, Plitidespin and Dexamethasone

Component-level concepts

Brand Name

Examples: Abatoarin, Acetisal, Aclacin

Component

Examples: abciximab, abemaciclib, abexinostat

Component Class

Examples: 5 alpha-reductase inhibitor, AKT1 inhibitor, anthracycline

Rad Sig

Example: 1.1 Gy fractions x 70 fractions, given twice per day, 5 times per week (total dose: 77 Gy)

Route

Examples: intravenous, oral, subcutaneous

Sig

Example: 0.4 mg/m^2/day IV continuous infusion over 96 hours, started on day 1 (total dose per cycle: 1.6 mg/m^2)

Sig Stub

Example: (dose not specified) IT once per day on days 22 and 43

Study-level concepts

Endpoint

Examples: CR rate after first induction, DFS36, OS

Experimental design

Examples: de-escalation, escalation, in-class switch, out-of-class switch

Study

Examples: ABSOLUTE, ACOSOG Z1031, ECOG E3483

Study Group

Examples: Eastern Cooperative Oncology Group, EINSTEIN Investigators, EORTC Children Leukemia Group

Study name short

Examples: Adelstein et al. 2003, Adelstein et al. 2010, Alberts et al. 1989