All-trans retinoic acid (ATRA)
General information
Class/mechanism: Retinoid, induces maturation/differentiation of acute promyelocytic leukemia (APL) cells. Exact mechanism unknown.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Tretinoin (Vesanoid) patient drug information (Chemocare)[3]
- Tretinoin (Vesanoid) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 11/22/1995: Initial FDA approval
Also known as
080 Antismallpox, A-acido, A-acido Emoliente, A-acido Vital, A-RET, A-tinic, A-vitaminsyre, A.A, Aberel, Aberela, AC.retinoic GI, Acfen-A, Acid A VIT, Acido Retinoico, Acido Vital, Acnavit, Acned, Acnelyse, Acretin, Acta, Acudyne, Adina, AI LI KE, Airful, Airol, Ajina, Aldoquin Anti-Acne, all-trans retinoic acid, Alquin-Gel, Alten, Altinac, Arretin, ATRA, Atrederm, Aviderm, Avita, Avitcid, Betarretin, Cordes VAS, Cosmotrin, Crometin-A, Date Film, Dermairol, Derma Lightening, Dermodan, Dermojuventus, Derugin, DI WEI, Effederm, Elra, EPI-Aberel, Eudyna, Extraderm, Facely, Facenol, Funoin, Hidrosam T, Jeraklin, Kefrane, Kerlocal, Ketrel, Locacid, Masc Retynowa, Melavita, Microvita, Neotretin, Nilac, Niterey, Nuface, Olcenon, Olcenon Kayaku, Quali-A, Recknoin, Rejuva-A, Renova, Retacnyl, Retavit, Reticne, Reticrem, Retiderm, Retigel, Retin-A Micro, Retin A, Retinei, Retino, Retino-A, Retino Forte, Retinoic Acid, Retinomycin, Retinova, Retirides, Retisol, Retisol-A, Retitop, Retop-A, Retrieve, Smooderm, Sorfic, Stieva A, Tracne, Tracnesan, Trena, Trentin, Tretin, Tretinax, Tretinex, Tretinoderm AC, Tretinoin, Tretinoina, Tretinoine Kefrane, Tretinoin Tocoferil, Tretinoinum, Tretinon, Trinon, Tronin, Vesaoid, VIT A Acid, Vitanol, Vitanol A, Vitinoin.