Wilms tumor

Section editor
	Wayne H. Liang, MD, MS Birmingham, AL LinkedIn Twitter: WayneLiangMD

3 regimens on this page 3 variants on this page

All lines of therapy

Dactinomycin monotherapy

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Regimen

Study	Evidence	Comparator	Efficacy
Wolff et al. 1968	Randomized (E)	Single course of dactinomycin	Seems to have superior RFS

Preceding treatment

• Surgical resection

Chemotherapy

• Dactinomycin (Cosmegen) 15 mcg/kg IV once per day on days 1 to 5

6-week cycle for 3 cycles, then 3-month cycle for 4 cycles

References

1. Wolff JA, Newton WA Jr, Krivit W, D'Angio GJ. Single versus multiple dose dactinomycin therapy of Wilms's tumor: a controlled co-operative study conducted by the Children's Cancer Study Group A (formerly Acute Leukemia Co-operative Chemotherapy Group A). N Engl J Med. 1968 Aug 8;279(6):290-4. link to original article PubMed
   1. Update: Wolff JA, D'Angio G, Hartmann J, Krivit W, Newton WA Jr. Long-term evaluation of single versus multiple courses of actinomycin D therapy of Wilms's tumor. N Engl J Med. 1974 Jan 10;290(2):84-6. link to original article contains verified protocol PubMed