Ondansetron (Zofran)
General information
Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.[1][2]
Route: PO, IV
Extravasation: no information available
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Patient counseling information can be found in the Ondansetron (Zofran) package insert[1]
- Ondansetron (Zofran) patient drug information (UpToDate)[3]
History of changes in FDA indication
- 1/4/1991: Initial FDA approval
Also known as
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Alencar | Amilene | ANG DAN Tong | Ansentron | Anset | AN SI XIN | AO YI MAI | Atossa |
Bryterol | Cedantron | Ceramos | Cloridrato DE Ondansetrona | Danofran | Dantenk | Emeran | Emeset |
Emetra | Emetron | Emigo | Emistat | Emivox | EN NUO Ping | Espasevit | Finaber |
Finoxi | Frazon | FU MI Ting | Glendan | Helmine | Injectrax | Insetron | Invomit |
Izofran | Latran | Modifical | Narfoz | Nausedron | Nautah | Neomit | Nuset |
O.N.D. | Odanex | Odanse | Ometic | Omstron | Onaset | Oncotor | Onda |
Ondace | Ondan | Ondanles | Ondansetron | Ondansetron-Z | Ondansetron Alpharma | Ondansetron CF | Ondansetron Denver Farma |
Ondansetron Epicaris | Ondansetron Fabra | Ondansetron Filaxis | Ondansetron Gobbi | Ondansetron Hydrochloride | Ondansetron Lazar | Ondansetron Martian | Ondansetron Nycomed |
Ondansetron ODT | Ondansetron Ratiopharm | Ondant | Ondaren | Ondasetron | Ondatie | Ondavell | Ondem |
Ondemet | Onfran | Onilat | Onsat | Onseran | Onset | Onsetron | Onsett |
Onsia | Ontrax | Onzod | Osetron | Ostasyn | Otobrol | Periset | Quimiofran |
Seton | Setronax | Setronon | SHI TAI | SN-307 | Sopran | Trorix | Vero Ondansetron |
Vomceran | Vomiban | Vomigo | Vomikind | Vomiset | Vomitron | Vomiz | Vonau |
WEI ZE | Yatrox | Zantron | Zapron | Zemitron | Zofer | Zofran | Zofran ODT |
Zofran Sankyo | Zofron | Zoltem | Zonax | Zondan | Zophren | Zudan |
References
- Italian Group for Antiemetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med. 2000 May 25;342(21):1554-9. link to original article PubMed