Thrombocytopenia in liver disease

Section editors
	Shruti Chaturvedi, MBBS, MSCI Baltimore, MD LinkedIn		Benjamin Tillman, MD Nashville, TN

See the thrombocytopenia reference page for general definitions and workup recommendations.

2 regimens on this page 2 variants on this page

Thrombocytopenia in liver disease with planned procedure

Avatrombopag monotherapy

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Regimen

Study	Evidence	Comparator	Efficacy
ADAPT-1	Phase III	Placebo	Superior RR
ADAPT-2	Phase III	Placebo	Superior RR

Therapy

• Avatrombopag (Doptelet) as follows:
  • Platelet count less than 40 x 10⁹/L: 60 mg PO once per day on days 1 to 5
  • Platelet count at least 40 and less than 50 x 10⁹/L: 40 mg PO once per day on days 1 to 5

Procedure days were days 10 to 13