Ifosfamide (Ifex)
General information
Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant
Note: A protective agent such as mesna should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Ifosfamide (Ifex) patient drug information (Chemocare)[3]
- Ifosfamide (Ifex) patient drug information (UpToDate)[4]
Also known as
Alquimid, Duvaxan, Fentul, Fosfidex, Haloxan, Holoxan, Holoxane, Ifex, IFO Cell, Ifocris, Ifolem, Ifomida, Ifomide, Ifos, Ifosfamida Delta Farma, Ifosfamida Filaxis, Ifosfamida Microsules, Ifosfamida Servycal, Ifoxan, IFX, Ipamide, Isophosphamide, Isoxan, Macdafen, Mitoxana, Mitoxana Lyophilisate, PI FU Ping, Trav Ifosfamide, Tronoxal, Vero Ifosfamide