Example orders for FOLFIRI in colon cancer
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FOLFIRI
FOLFIRI: FOLinic acid, Fluorouracil, IRInotecan
Original references may be found at FOLFIRI
Example regimen #1
- Folinic acid (Leucovorin) 400 mg/m2 IV over 2 hours on day 1, given during irinotecan infusion
- Fluorouracil (5-FU) 400 mg/m2 IV bolus over 10-15 minutes on day 1, given after irinotecan and leucovorin
- Fluorouracil (5-FU) 1200 mg/m2/day IV continuous infusion over 46 hours on days 1-2, given last after bolus 5-FU
- Irinotecan (Camptosar) 180 mg/m2 IV over 90 minutes on day 1, given first together with leucovorin
14-day cycles
Supportive medications:
- Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy
- Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy
- Lorazepam (Ativan) 0.5-1 mg PO/IV prn nausea/anxiety
- Atropine 0.4 mg IV prn diaphoresis, visual changes, abdominal cramping, or diarrhea during or after irinotecan infusion
Monitoring:
- Hold if ANC <1000 or platelets <100 and notify physician.
Outpatient medications:
- Loperamide (Imodium) 4 mg PO x1 for each day's first episode of diarrhea; 2 mg PO prn each loose stool thereafter, up to a maximum of 16 mg per day