Example orders for FOLFIRI in colon cancer

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Remember that example order sets that may contain additional information about supportive medications, suggestions for monitoring, hydration, and pre-treatment screening information for chemotherapy regimens are purely anecdotal, provided only as examples of what some other providers may be using, and are typically not based on references in the primary literature.


FOLFIRI: FOLinic acid, Fluorouracil, IRInotecan

Original references may be found at FOLFIRI

Example regimen #1

14-day cycles

Supportive therapy

  • Ondansetron (Zofran) 8 mg IV 30 minutes prior to chemotherapy
  • Dexamethasone (Decadron) 10 mg IV 30 minutes prior to chemotherapy
  • Lorazepam (Ativan) 0.5-1 mg IV or PO prn nausea/anxiety
  • Atropine 0.4 mg IV prn diaphoresis, visual changes, abdominal cramping, or diarrhea during or after irinotecan infusion


  • Hold if ANC less than 1000 or platelets less than 100 and notify physician.

Outpatient medications:

  • Loperamide (Imodium) 4 mg PO x1 for each day's first episode of diarrhea; 2 mg PO prn each loose stool thereafter, up to a maximum of 16 mg per day