NovoTTF-100A system (Optune)
Also known as the NovoTTF-100A System.
General information
Class/mechanism: External portable device which delivers electric tumor treating fields (TTFields) via insulated transducer arrays placed on the patient's skin close to glioblastoma multiforme (GBM) tumors. TTFields affect dividing cells by two main mechanisms. First, they disrupt microtubule spindle formation during anaphase, in which tubulin, a highly electrically polar molecule, normally forms polymers. Exposure to TTFields prevents tubulin from being able to align properly and promotes depolymerization of mitotic spindles. Second, the TTFields disrupt the cleavage plane between the two daughter cells during late telophase. These actions halt cell division, cause abnormal spindle formation, disrupt regular chromosome separation, and result in apoptosis.[1][2][3][4]
Route: external portable device
Extravasation: n/a