Alvocidib (Flavopiridol)

Mechanism of action

Flavonoid alkaloid CDK9 kinase inhibitor
Route: PO

Diseases for which it is used

• Acute myeloid leukemia
• Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)

History of changes in FDA indication

• 4/13/2007: Granted orphan status for treatment of B-cell chronic lymphocytic leukemia (B-CLL) or prolymphocytic leukemia arising from CLL.
• 4/23/2014: Granted orphan designation for the treatment of patients with acute myeloid leukemia (AML)