Example orders for 5-FU & low-dose Leucovorin (Mayo Clinic regimen - LDLV) in colon cancer

Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.

5-FU & low-dose Leucovorin (Mayo Clinic regimen/LDLV)

Original references may be found at 5-FU & low-dose Leucovorin (Mayo Clinic regimen/LDLV) (adjuvant) & 5-FU & low-dose Leucovorin (Mayo Clinic regimen/LDLV) (metastatic)

Example regimen #1

• Folinic acid (Leucovorin) 20 mg/m2 IV over 15-30 minutes on days 1-5, given first before 5-FU
• Fluorouracil (5-FU) 425 mg/m2 IV push on days 1-5, given after leucovorin

28-day cycles x 6 cycles for adjuvant therapy; in metastatic settings, given until progression of disease or unacceptable toxicity

Supportive medications:

• Prochlorperazine (Compazine) 10 mg PO 30 minutes prior to chemotherapy

Hydration:

• 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.

Monitoring:

• Hold if ANC <1000 and platelets <100 and notify physician.