Isotretinoin (Accutane)
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Mechanism of action
From the NCI Drug Dictionary: A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
Diseases for which it is used
Also known as
- Code name: Ro 4-3780
- Generic names: 13-cis-retinoic acid, 13-cis-vitamin A acid, cis-retinoic acid, isotretinoinum, neovitamin A
- Brand names: Accure, Accutane, Amnesteem, Cistane, Claravis, Isotrex, Isotrexin, Oratane, Roaccutan, Roaccutane, Roacutan, Sotret