Example orders for weekly 5-FU & Leucovorin in colon cancer

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Weekly 5-FU & Leucovorin

Original reference may be found at weekly 5-FU & Leucovorin

Example regimen #1

• Folinic acid (Leucovorin) 20 mg/m2 IV over 2 hours on days 1, 8, 15, given first
• Fluorouracil (5-FU) 500 mg/m2 IV bolus on days 1, 8, 15, given 1 hour after start of leucovorin

28-day cycles

Supportive medications:

• Prochlorperazine (Compazine) 10 mg PO prn nausea

Hydration:

• 500 ml NS at KVO rate as running IV for chemotherapy infusion. Give up to 500 ml NS.

Monitoring:

• Hold if patient has significant diarrhea/mucositis, ANC <1000, or platelets <100 and notify physician.

Comments:

• My institution administers this regimen with a 3 weeks on, 1 week off schedule for every 28-day cycle.