Cabozantinib (Cometriq)
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General information
Class/mechanism: Tyrosine kinase inhibitor; inhibits RET, MET/c-Met, VEGFR-1, VEGFR-2, VEGFR-3, KIT, TRKB, FLT-3, AXL, and TIE-2.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Cabozantinib (Cometriq) package insert pages 20-24[1] (the numbering for the PDF is off, so in some PDF viewers, the patient information is on pages 27-31)
- Cabozantinib (Cometriq) patient drug information (Chemocare)[4]
- Cabozantinib (Cometriq) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 11/29/2012: FDA approved for treatment of "progressive metastatic medullary thyroid cancer (MTC)"
- 4/25/2016: FDA approved for the treatment of advanced renal cell carcinoma in patients who have received prior anti-angiogenic therapy.
Also known as
XL184 or XL-184.