Colorectal cancer, KRAS-mutated

From HemOnc.org - A Hematology Oncology Wiki
Revision as of 15:34, 31 May 2023 by Warner-admin (talk | contribs) (Text replacement - "(NCT[0-9]{8})" to "[https://clinicaltrials.gov/ct2/show/$1 Clinical Trial Registry]")
Jump to navigation Jump to search

Section editor transclusions Note: the page has regimens specific to BRAF-mutated colon cancer.

5 regimens on this page
8 variants on this page


Advanced or metastatic disease, subsequent lines of therapy

Adagrasib monotherapy

Regimen

Study Dates of enrollment Evidence
Yaeger et al. 2022 (KRYSTAL-1) NR in abstract Phase 1/2

Biomarker eligibility criteria

  • KRAS p.G12C mutation

Targeted therapy

Continued indefinitely

References

  1. KRYSTAL-1: Yaeger R, Weiss J, Pelster MS, Spira AI, Barve M, Ou SI, Leal TA, Bekaii-Saab TS, Paweletz CP, Heavey GA, Christensen JG, Velastegui K, Kheoh T, Der-Torossian H, Klempner SJ. Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C. N Engl J Med. 2023 Jan 5;388(1):44-54. Epub 2022 Dec 21. link to original article contains dosing details in abstract link to PMC article PubMed Clinical Trial Registry

Adagrasib & Cetuximab

Regimen variant #1

Study Dates of enrollment Evidence
Yaeger et al. 2022 (KRYSTAL-1) NR in abstract Phase 1/2

Biomarker eligibility criteria

  • KRAS p.G12C mutation

Targeted therapy

7-day cycles


Regimen variant #2

Study Dates of enrollment Evidence
Yaeger et al. 2022 (KRYSTAL-1) NR in abstract Phase 1/2

Biomarker eligibility criteria

  • KRAS p.G12C mutation

Targeted therapy

14-day cycles

References

  1. KRYSTAL-1: Yaeger R, Weiss J, Pelster MS, Spira AI, Barve M, Ou SI, Leal TA, Bekaii-Saab TS, Paweletz CP, Heavey GA, Christensen JG, Velastegui K, Kheoh T, Der-Torossian H, Klempner SJ. Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C. N Engl J Med. 2023 Jan 5;388(1):44-54. Epub 2022 Dec 21. link to original article contains dosing details in abstract link to PMC article PubMed Clinical Trial Registry