Forodesine (Fodosine)

Mechanism of action

From the NCI Drug Dictionary: The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes.

Diseases for which it is used

• Peripheral T-cell lymphoma

Also known as

• Code name: BCX-1777
• Generic name: immucillin H
• Brand name: Fodosine, Mundesine