Leucovorin (Folinic acid)
General information
Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Cervical cancer
- Colon cancer
- Esophageal cancer
- Gastric cancer
- Hepatobiliary cancer
- Non-Hodgkin lymphoma
- Pancreatic cancer
- Rectal cancer
Patient drug information
- Folinic acid (Leucovorin) patient drug information (Chemocare)[3]
- Folinic acid (Leucovorin) patient drug information (UpToDate)[4]
Also known as
Abic Leucovorin, AC.folinico GI, AI JIE Kang, Antrex, Asovorin, Biovorin, BO Sheng, Buateron, Calcifolin, Calcio Folinato, Calciumfolin, Calciumfolinat, Calciumfolinat-GRY, Calciumfolinat Ebewe, Calciumfolinat Hexal, Calciumfolinat Mayne, Calcium Folinato, Calcium Folint, Calcium Leucovorin, Calcium Leucovorn, Calcivoran, Calc Leucovorn, Calfolex, Calfolin, Calinat, Cehafolin, Citofolin, Citrovorum Factor, Claro, Cromatonbic Folinico, Dalisol, Degalin, Divifolin, Durofolin, Ecofol, Elvefocal, Emovis, Erbanfol, Estroquin, Fastovorin, Fauldleuco, Fayining, Fedolen, Ferbon, Folaren, Folaxin, Foliben, Folic Acid Roche, Foli Cell, Folidan, Folidar, Foliment, Folinac, Folinate Calcium, Folinate DE Calcium Aguettant, Folinate DE Calcium Dakota Pharm, Folinato, Folinato Calcico, Folinato Calcico Ferrer, Folinato DE Calcio, Folinfabra, Folinoral, Folinoxan, Folinvit, Foliplus, Folmigor, FU LI Neng, Ifavor, Isovorin, Kalciumfolinat Perivita, Kalsiumfolinat, Kunyrin, Lederfolat, Lederfolin, Lederfoline, Lederle Leucovorin, Ledervorin, Legifol, Leucocalcin, Leuconolver,Leucovorin, Leucovorina, Leucovorina Calcica, Leucovorina Calcica Teva, Leucovorina Calcico, Leucovorina Delta Farma, Leucovorina Filaxis, Leucovorina Raffo, Leucovorina Richet, Leucovorina Servycal, Leucovorin CA, Leucovorin Calcium, Leucovorin Calcium Farmos, Leucovorin Dabur, Leucovorine, Leucovorine Calcium, Leucovorin Lens, Leucovorin Teva, Leukovorin, Lovorin, Medicofolin, Medifolin, Medsavorina, Neofolin, Nyrin, O Folin, Osfolate, Osfolato, Perfolate, Prefolic, Prevax, Recovorin, Reotan, Rescuvolin, Resfolin, Ribofolin, Rontafor, Sanifolin, SHI Ming, Sodium Folinate, Tecnovorin, Tong AO, Tonofolin, Veravorin, Vorina, Wellcovorin, Zyofolin, Zytofolin