Difference between revisions of "Ipilimumab (Yervoy)"
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
*3/25/2011: [http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm1193237.htm FDA approved] "for the treatment of unresectable or metastatic [[Melanoma | melanoma]]." | *3/25/2011: [http://www.fda.gov/newsevents/newsroom/pressannouncements/ucm1193237.htm FDA approved] "for the treatment of unresectable or metastatic [[Melanoma | melanoma]]." | ||
| + | *10/28/2015: [http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm469944.htm FDA approved] for "adjuvant treatment of patients with cutaneous [[Melanoma | melanoma]] with pathologic involvement of regional lymph nodes of more than 1 mm who have undergone complete resection, including total lymphadenectomy." | ||
==Also known as== | ==Also known as== | ||
Revision as of 07:49, 30 October 2015
General information
Class/mechanism: Anti-CTLA-4 antibody. CTLA-4 is a negative regulator of T-cell activation and ipilimumab interferes with the ability of CTLA-4 to interact with its ligands CD80/CD86. CTLA-4 blockade results in T-cell activation and proliferation, and it is suspected that its anti-neoplastic activity may be due to T-cell mediated anti-tumor immune responses.[1][2][3]
Route: IV
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Ipilimumab (Yervoy) package insert[1]
- Ipilimumab (Yervoy) patient drug information (Chemocare)[5]
- Ipilimumab (Yervoy) patient drug information (UpToDate)[6]
History of changes in FDA indication
- 3/25/2011: FDA approved "for the treatment of unresectable or metastatic melanoma."
- 10/28/2015: FDA approved for "adjuvant treatment of patients with cutaneous melanoma with pathologic involvement of regional lymph nodes of more than 1 mm who have undergone complete resection, including total lymphadenectomy."
Also known as
BMS-734016 or MDX-010.
References
- ↑ 1.0 1.1 1.2 Ipilimumab (Yervoy) package insert
- ↑ Ipilimumab (Yervoy) package insert (locally hosted backup)
- ↑ Yervoy manufacturer's website
- ↑ YERVOY Risk Evaluation and Mitigation Strategy (REMS) Site
- ↑ Ipilimumab (Yervoy) patient drug information (Chemocare)
- ↑ Ipilimumab (Yervoy) patient drug information (UpToDate)