Difference between revisions of "CNS lymphoma - null regimens"
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<div class="toccolours" style="background-color:#cbd5e8"> | <div class="toccolours" style="background-color:#cbd5e8"> | ||
====Preceding treatment==== | ====Preceding treatment==== | ||
| − | *G-PCNSL-SG-1, before 2006: [[CNS_lymphoma#Methotrexate_monotherapy_2|High-dose methotrexate]] x 6 | + | *G-PCNSL-SG-1, before 2006: Induction [[CNS_lymphoma#Methotrexate_monotherapy_2|High-dose methotrexate]] x 6 |
| − | *G-PCNSL-SG-1, after 2006: [[CNS_lymphoma#Ifosfamide_.26_Methotrexate|High-dose methotrexate & ifosfamide]] x 6 | + | *G-PCNSL-SG-1, after 2006: Induction [[CNS_lymphoma#Ifosfamide_.26_Methotrexate|High-dose methotrexate & ifosfamide]] x 6 |
</div></div> | </div></div> | ||
===References=== | ===References=== | ||
Revision as of 12:46, 13 April 2024
The purpose of this page is to provide references to "null therapy" such as placebo and observation. These references provide further insight into the historical development of the treatment landscape. See the main CNS lymphoma page for regimens that include active anticancer treatment.
Consolidation after upfront therapy
Observation
Regimen
| Study | Dates of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Thiel et al. 2010 (G-PCNSL-SG-1) | 2000-2009 | Phase 3 (E-de-esc) | Whole-brain irradiation | Inconclusive whether non-inferior OS |
No further treatment.
Preceding treatment
- G-PCNSL-SG-1, before 2006: Induction High-dose methotrexate x 6
- G-PCNSL-SG-1, after 2006: Induction High-dose methotrexate & ifosfamide x 6
References
- G-PCNSL-SG-1: Thiel E, Korfel A, Martus P, Kanz L, Griesinger F, Rauch M, Röth A, Hertenstein B, von Toll T, Hundsberger T, Mergenthaler HG, Leithäuser M, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Plasswilm L, Nägele T, Pietsch T, Bamberg M, Weller M. High-dose methotrexate with or without whole brain radiotherapy for primary CNS lymphoma (G-PCNSL-SG-1): a phase 3, randomised, non-inferiority trial. Lancet Oncol. 2010 Nov;11(11):1036-47. Epub 2010 Oct 20. link to original article PubMed NCT00153530
- Update: Korfel A, Thiel E, Martus P, Möhle R, Griesinger F, Rauch M, Röth A, Hertenstein B, Fischer T, Hundsberger T, Mergenthaler HG, Junghanß C, Birnbaum T, Fischer L, Jahnke K, Herrlinger U, Roth P, Bamberg M, Pietsch T, Weller M. Randomized phase III study of whole-brain radiotherapy for primary CNS lymphoma. Neurology. 2015 Mar 24;84(12):1242-8. Epub 2015 Feb 25. link to original article PubMed