Difference between revisions of "Pentraxin 2 (PRM-151)"
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[[Category:Myelofibrosis medications (investigational)]] | [[Category:Myelofibrosis medications (investigational)]] | ||
Latest revision as of 14:32, 28 February 2024
General information
Class/mechanism per NCI Drug Dictionary: A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid P/pentraxin 2 (PRM-151) may inhibit myofibroblast generation by preventing the differentiation of circulating monocytes into fibrocytes and profibrotic macrophages. PTX2 is a circulating plasma protein that belongs to the class of pattern recognition receptors (PRR) of the innate immune system.
Route: IV
Extravasation: n/a
Preliminary data
Myelofibrosis
Also known as
- Code name: PRM-151