Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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==Guidelines== | ==Guidelines== | ||
==="How I Treat"=== | ==="How I Treat"=== | ||
− | *'''2022:''' Stanworth & Shah [https://doi.org/10.1182/blood.2022016558 How I use platelet transfusions] | + | *'''2023:''' Stanworth & Mumford [https://doi.org/10.1182/blood.2022018017 How I diagnose and treat neonatal thrombocytopenia] [https://pubmed.ncbi.nlm.nih.gov/36787503/ PubMed] |
+ | *'''2022:''' Stanworth & Shah [https://doi.org/10.1182/blood.2022016558 How I use platelet transfusions] [https://pubmed.ncbi.nlm.nih.gov/35926105/ PubMed] | ||
*'''2022:''' Fiore et al. [https://doi.org/10.1182/blood.2021011595 How I manage pregnancy in women with Glanzmann thrombasthenia] | *'''2022:''' Fiore et al. [https://doi.org/10.1182/blood.2021011595 How I manage pregnancy in women with Glanzmann thrombasthenia] | ||
*'''2021:''' Kyrle & Eichinger [https://doi.org/10.1182/blood.2020008218 How I manage cyclic thrombocytopenia] | *'''2021:''' Kyrle & Eichinger [https://doi.org/10.1182/blood.2020008218 How I manage cyclic thrombocytopenia] |
Revision as of 21:38, 5 June 2023
Guidelines
"How I Treat"
- 2023: Stanworth & Mumford How I diagnose and treat neonatal thrombocytopenia PubMed
- 2022: Stanworth & Shah How I use platelet transfusions PubMed
- 2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
- 2021: Kyrle & Eichinger How I manage cyclic thrombocytopenia
Definition of thrombocytopenia
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP